The purpose of this article has been to show what social sciences can contribute to advance in the knowledge and understanding of personal and social problems derived from suffering from rare vision diseases. It concludes that the incorporation of data in the National Patient Registries is an opportunity to encourage research into the problems existing in our social and cultural context, in the search for solutions that will lead to improvements in treatment, health care, psycho-social care, education, employment, etc. and (...) in the evaluation of results. In short, in the conditions and quality of life of patients and their families. (shrink)

Batteries are a fundamental storage component due to its various applications in mobility, renewable energies and consumer electronics among others. Regardless of the battery typology, one key variable from a user’s perspective is the remaining energy in the battery. It is usually presented as the percentage of remaining energy compared to the total energy that can be stored and is labeled State Of Charge (SOC). This work addresses the development of a hybrid model based on a Lithium Iron Phosphate (LiFePO4) (...) power cell, due to its broad implementation. The proposed model calculates the SOC, by means of voltage and electric current as inputs and the latter as the output. Therefore, four models based on k-Means, Agglomerative Clustering, Gaussian Mixture and Spectral Clustering techniques have been tested in order to obtain an optimal solution. (shrink)

Rho proteins belong to the small GTPases superfamily. They function as molecular switches that, in response to diverse stimuli, control key signaling and structural aspects of the cell. Although early studies proposed a role for Rho GTPases in cellular transformation, this effect was underestimated due to the fact that no genetic mutations affecting Rho‐encoding genes were found in tumors. Recently, it has become evident that Rho GTPases participate in the carcinogenic process by either overexpression of some of the members of (...) the family with oncogenic activity, downmodulation of other members with suggested tumor suppressor activity, or by alteration of upstream modulators or downstream effectors. Thus, alteration of the levels of expression of different members of the family of Rho GTPases has been detected in many types of human tumors leading to a great interest in the cellular effects elicited by these oncoproteins. This essay reviews the current evidence of dysregulation of Rho signaling by overexpression in human tumors. BioEssays 27:602–613, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

I _Sogni di un visionario chiariti con sogni della metafisica_ del 1766 sono sempre stati visti come un'opera unica all'interno dell'intera produzione filosofica di Kant. Se tradizionalmente si è visto in questo scritto il momento di massima vicinanza a Hume e quindi di massimo scetticismo antimetafisico da parte di Kant, negli ultimi tre decenni non sono mancate letture che hanno visto in esso non soltanto una continuità con la metafisica kantiana precedente ma anche un interesse vero e genuino da parte (...) di Kant per le teorie del mistico svedese Emanuel Swedenborg (1688-1772). Tuttavia, nessuna di queste letture ha riservato un'attezione adeguata al terzo capitolo della prima parte dei _Sogni_, nel quale Kant prende in esame i "sognatori della ragione" e i "sognatori della sensazione". Si tratta di una sezione del testo particolarmente interessante perché stabilisce quello stesso confronto fra errore metafisico ed errore empirico che Kant stabilisce quindici anni più tardi nella C_ritica della ragion pura_. L'esame del confronto fra questi due luoghi testuali permette dunque di vedere come si è evoluta la concezione kantiana dell'errore dal 1766 al 1781, e permette conseguentemente di capire in cosa la teoria dell'errore presente nella _Critica _si distingua essenzialmente da quella presente nei _Sogni_. (shrink)

The aim of this study was to carry out a psychosocial analysis of child-to-parent violence (CPV) in a sample of school adolescents, considering a set of individual variables (psychological distress, problematic use of social networking sites, and perceived non-conformist social reputation) and family variables (open and problematic communication with parents) according to sex. The sample consisted of 3,731 adolescents (54% boys), aged between 14 and 16 years (M = 14.6 years, SD = 0.567), from the state of Nuevo León, Mexico. (...) The scores of the boys and girls were analyzed to check for differences. Also, correlations between all the study variables were calculated. Finally, a multiple stepwise regression analysis was carried out for the total sample and also for boys and girls separately. Results confirmed the important role of individual variables as predictors of CPV in boys and girls. The main difference between boys and girls was observed in the predictive weight of problematic use of social networking sites, which was higher in girls than in boys. Open communication with the father was a significant factor for predicting the decrease of CPV levels in the case of boys, while open communication with the mother predicted the decrease of CPV in girls. Problematic communication with the mother showed similar values in boys and girls when predicting CPV, however, the predictive weight of problematic communication with the father was higher in girls than in boys. These results are interesting and have important implications for the prevention of CPV. (shrink)

Background: Serious games have shown positive results in increasing motivation, adherence to treatment and strengthening the therapeutic alliance in multiple psychiatric disorders. In particular, patients with impulse control disorders and other disorders in which the patient suffers from inhibitory control deficits have been shown to benefit from serious games.Aim: The aim of this study was to describe the characteristics and to evaluate the usability of a new serious videogame, e-Estesia. This serious videogame was designed to improve emotion regulation in patients (...) with gambling disorder. Preliminary results from a pilot sample are also reported.Method: A pilot sample of 26 patients undergoing treatment for GD was recruited. Participants used e-Estesia on a tablet, which was connected to a thoracic band that sent heart rate and heart rate variability data to the videogame platform in order to provide biofeedback. The System Usability Scale was completed by patients to determine the usability of e-Estesia.Results and Discussion: e-Estesia performed comparatively well for all the explored groups. Around 84.6% of the patients endorsed that it was easy to use. Female patients with GD presented higher HRV during the use of the serious videogame compared to men. (shrink)

Pick-and-roll is the most widespread cooperative action among high-level basketball teams and the most applied strategy by coaches to gain an advantage over the rival team. During pick-and-roll, opposing teams perform antagonistic actions based on goals that are expressed in offensive and defensive tactics. The aim of this study is to examine the approaches of high-level coaches on the offensive and defensive dynamics emerging in matches of a basketball elite team during an entire season of the Spanish Asociación de Clubes (...) de Baloncesto league. To this end, we used a mixed-methods approach based on systematic observation of verbatim transcripts of interviews conducted with six high-level coaches about the pick-and-roll dynamics that emerged in matches of the Unicaja Málaga team during an entire season of the ACB league. The observational design was nomothetic, punctual, and multidimensional. The choice of this methodology is justified since we developed an ad hoc indirect observation tool to evaluate the coaches’ perspective on this dynamic. Once the intra-observer reliability of the instrument was confirmed, we performed a polar coordinate analysis to identify the significant relationships between the coaches’ evaluations and the offensive and defensive pick-and-roll elements that supported such verbal behaviors. The results highlight the presence of various offensive and defensive aspects of pick-and-roll emerging in the Unicaja team that were significantly associated with positive and negative evaluations of the coaches. The interview confirms that coach 1 and his staff were less confident in options that pick-and-roll offer, which is also reflected in the record of screens made and simulated, than coach 3. This study shows that the application of mixed methods, by analysis of the polar coordinate of the coding carried out on responses of a systematized interview, has proven to be an effective strategy in obtaining relevant information on the expert knowledge of the elite coaches on the influence of pick-and-roll on tactical actions in basketball. (shrink)

This paper aims to enhance security in IoT device networks through a visual tool that utilizes three projection techniques, including Beta Hebbian Learning (BHL), t-distributed Stochastic Neighbor Embedding (t-SNE) and ISOMAP, in order to facilitate the identification of network attacks by human experts. This work research begins with the creation of a testing environment with IoT devices and web clients, simulating attacks over Message Queuing Telemetry Transport (MQTT) for recording all relevant traffic information. The unsupervised algorithms chosen provide a set (...) of projections that enable human experts to visually identify most attacks in real-time, making it a powerful tool that can be implemented in IoT environments easily. (shrink)

El budismo actual presenta dos grandes ramas. La más antigua es la hinayana, el “pequeño vehículo”, representado actualmente por la escuela Theravada, arraigada fundamentalmente en Birmania, Laos, Tailandia, Camboya, Sri Lanka y Malasia. La otra, es el budismo mahayánico, el “gran vehículo”, surgido en el siglo segundo antes de nuestra era, y característico de China, Mongolia, Corea, Tíbet y Japón, y de la cual el budismo zen es una de su principales expresiones. La escuela Theravada tiene c..

Los estudios sobre el perfil de los aspirantes a la educación superior son escasos. Se compararon cuantitativamente características familiares, socioeconómicas y académicas de los aspirantes a la Licenciatura en Educación Primaria de las escuelas normales públicas de Baja California y Puebla. Perfil: mujer, soltera, 18 años, egresada de bachillerato general escolarizado. Se identificaron características más favorables en Baja California.

"Hay quien va por la vida viéndola, dejándose sorprender por la existencia". Esta obra es una aproximación laica a los fundamentos de la experiencia mística. Ayudándose de pensadores contemporáneos como Eugenio Trías, Marià Corbí o María Zambrano, la autora fundamenta el silencio de sí como peculiar vía de conocimiento y explora las formas en las que éste pueda favorecerse. Es una invitación a adentrarse en la lucidez asombrada como núcleo de una experiencia de vida plenamente humana. Mediante la relectura (y (...) el redescubrimiento) de los maestros del camino interior -exploradores del conocimiento silencioso-, se pondrá en evidencia la práctica de un peculiar esfuerzo de desegocentración como medio de sutilización de las capacidades humanas. La exploración de La nube del no-saber, del Bhagavad Gîta, o de las obras de Maestro Eckhart, Rûmî, Al-Yîlî, Lanfranchi, Juan de la Cruz, Teresa de Jesús, Nisargadatta Maharaj o Yoka Daishi entre otros, nos acerca a unas lecciones de vida que, nacidas de la experiencia mística, dejarán al descubierto la aportación propia e insustituible de ese rico legado. (shrink)

Rapid Automatized Naming is considered a universal marker of developmental dyslexia and could also be helpful to identify a reading deficit in minority-language children, in which it may be hard to disentangle whether the reading difficulties are due to a learning disorder or a lower proficiency in the language of instruction. We tested reading and rapid naming skills in monolingual Good Readers, monolingual Poor Readers, and MLC, by using our new version of RAN, the RAN-Shapes, in 127 primary school students. (...) In line with previous research, MLC showed, on average, lower reading performances as compared to mGR. However, the two groups performed similarly to the RAN-Shapes task. On the contrary, the mPR group underperformed both in the reading and the RAN tasks. Our findings suggest that reading difficulties and RAN performance can be dissociated in MLC; consequently, the performance at the RAN-Shapes may contribute to the identification of children at risk of a reading disorder without introducing any linguistic bias, when testing MLC. (shrink)

El propósito principal de este artículo es presentar un modelo teórico-metodológico de estudios del discurso desde una perspectiva social e ideológica y precisar el papel de los recursos interpersonales del lenguaje para dar cuenta de la explicación de fenómenos sociales. De manera particular se describe y explica el potencial analítico que ofrece el sistema de valoración para los estudios del discurso. Con el objeto de dar cuenta de una manera comprehensiva de este sistema, se ilustra cada uno de los sub-sistemas (...) y categorías propuestas con ejemplos provenientes de un corpus oral y escrito sobre las prácticas discursivas de transmisión pedagógica de las memorias históricas de un pasado reciente de violación a los derechos humanos cometidos durante la dictadura civil-militar de Augusto Pinochet en Chile. (shrink)

Sobre la base de una revisión historiográfica se analizan los vínculos entre medicina, historia de la medicina e historia de las mujeres y se muestra el papel de la historia de la medicina no androcéntrica como introductora, en el campo de la salud, cíe conceptos teóricos del feminismo, el género principalmente, que están permitiendo transformar el conocimiento médico sobre el cuerpo y valorar las prácticas de las mujeres sanitarias.

Revisión del libro Escritos desobedientes. Historias de hijas, hijos y familiares de genocidas por la memoria, la verdad y la justicia por A. Kalinec (comp.).

Proponemos explorar la tradición del testimonio latinoamericano marcando dos modelos. En primer lugar, revisamos el testimonio de matriz revolucionaria, institucionalizado en 1970 por Casa de las Américas bajo el paradigma revolucionario y en cuyo interior analizamos tres tipos diferentes –el testimonio etnográfico, guerrillero y periodístico–. En segundo lugar abordamos la reinstitucionalización del testimonio bajo la narrativa de los Derechos Humanos hacia la década del 1980, focalizando en el caso Argentino. Nos interesa indagar los estatutos de cada modelo así como sus (...) vínculos con el campo literario. (shrink)

Las personas mayores, como grupo poblacional, son objeto de estereotipos y prejuicios hacia la vejez que derivan en situaciones de discriminación y edadismo. El presente estudio cualitativo indaga en la concepción y las atribuciones sociales a la vejez en las sociedades posindustriales, centrándose en el caso de Alemania y España. Para ello, a través de las técnicas de la entrevista y el grupo focal, se recaba la perspectiva tanto de expertos en el tema como de las propias personas mayores. El (...) análisis evidencia la imprecisión del concepto vejez y las connotaciones negativas asociadas al mismo, así como un rechazo a autoidentificarse como persona mayor. Se concluye la necesidad de una reconceptualización de la vejez que refleje su significado actual. (shrink)

The main implication of the scientific consensus on human causality of climate change is the need to implement urgent and transformative policies. However, inaction remains. Much of the academic research has concentrated on discourses that question the evidence of climate science under the umbrella term "climate change denial", but the focus has recently started to shift to the arguments of those who, while accepting the evidence, criticize the processes by which it is obtained and, especially, oppose ambitious measures, in many (...) cases using misinformation. In this article, we will present a taxonomy of such arguments, categorized under the concept of "climate action obstructionism", and we will analyze how this discourse is "amplified" through the Internet; specifically, as an example, we will examine a YouTube video posted on Dalas Review’s channel. (shrink)

En este texto se aborda la cuestión del tipo de violencia que llevó a la matanza de Tlatelolco, en 1968, y a la desaparición de los estudiantes de Ayotzinapa en la llamada “noche de Iguala”, 46 años después. El primero fue el suceso más relevante después de la Revolución mexicana; el segundo, desnudó la colusión de un Estado corrupto con el crimen organizado. Sin duda, en ambos acontecimientos hay una violencia estructural e institucional atribuible al Estado. No obstante, es necesario (...) ir más allá para señalar las particularidades de cada uno y la manera como se vinculan, a pesar de las décadas que los separan. (shrink)

Este artículo se enfoca en la concepción kantiana de un derecho de guerra, en particular en la controversial figura del enemigo injusto del apartado “Derecho de gentes” de la Rechtslehre, que ha dado pie a que se considere a Kant un teórico de la guerra justa (e. g. Carl Schmitt y B. Orend). Rechazo dicha interpretación y defiendo que al filósofo alemán no se le puede colocar esta etiqueta sin desvirtuar su visión crítica de la guerra, lo que supone comprender, (...) por una parte, la función de esta en el progreso de la humanidad, y, por otra, aceptar el veto de la razón práctica que la prohíbe. Con ese propósito retomo la defensa que hace Howard Williams frente a B. Orend e intento imprimir mayor fuerza a su argumento incorporando la noción de “ley permisiva” al derecho de guerra que se emprende contra el enemigo injusto. (shrink)